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Grants to USA, Canada, and International Researchers
for Collaborative Studies Related to Epilepsy

Rare Epilepsy Partnership Award

Agency Type:

Foundation / Corporation

Funding Source:

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Citizens United for Research in Epilepsy (CURE)

LOI Date:


Deadline Date:

09/13/22 9:00 PM ET


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Grants to USA, Canada, and International researchers affiliated with IHEs or research institutions for studies related to uncommon forms of epilepsy. Applicants are required to submit a letter of intent prior to a full grant application. Funding is intended to support collaborative research between the investigator and rare epilepsy advocacy groups.

CURE Epilepsy’s grant programs seek to accelerate promising research leading to new treatments and cures for people living with epilepsy. CURE Epilepsy prioritizes innovative projects that address its mission, affirming CURE's core belief that the only acceptable final goal is “no seizures, no side-effects.”

Rare Epilepsy Partnership Award will support the development of necessary research tools, techniques, model systems, and data collection platforms to stimulate and accelerate research on rare epilepsies. Each award will be co-funded by CURE Epilepsy and one or more of the rare epilepsy advocacy groups (partners) identified in the Request For Proposals. Applications must focus on one or more of the specific rare epilepsies that are represented by each group as well as address CURE Epilepsy’s mission to cure epilepsy.

Applications must clearly identify the rare epilepsy(ies) that the research is directed towards. General priority areas for this program include:

  • Development of rare epilepsy-specific cellular models including but not limited to patient-derived stem cells, iPSC lines, 3D organoid models or fused organoid models.
  • Development of appropriate genetic animal models.
  • Development of novel in-vitro or in-vivo assays or techniques, for example, drug screening platforms, to enhance research in rare epilepsy.
  • Development of research tools and novel techniques to enhance understanding of the cellular, molecular, genetic, and systems-level biology that leads to rare epilepsy, as well as facilitate the investigation of disease-modifying or preventative strategies.
  • Supporting registries to better understand the natural history of one or more rare epilepsies or to look across rare epilepsies to identify common therapeutic targets and/or pathways. Projects utilizing existing registries or databases are allowed and must clearly articulate the specific rare epilepsy that will be studied. Use of registry platforms that ensure patient access to their data and when appropriate integrate with existing data collection platforms to enable data sharing with researchers and patient advocacy groups is strongly encouraged.
  • Use of Electronic Health Record data to better understand the disease burden of rare epilepsy and develop therapeutic strategies.
  • Development of technologies that will accelerate accurate diagnoses for rare epilepsies. 

An overarching goal of this funding mechanism is to develop resources and data that will be made available to the research community to accelerate research on rare epilepsies. For partner-specific research priorities, see:

Budgets may include salary support for the Principal Investigator (PI), technical staff and/or co-PIs, supplies, animal costs, vendor costs, limited equipment cost, and travel to an epilepsy-related conference only if the PI is presenting his/her CURE Epilepsy-funded research.

GrantWatch ID#:

GrantWatch ID#: 203479

Estimated Size of Grant:

Requests may be made for up to a maximum of $100,000. CURE Epilepsy reserves the right to fund only select specific aims or stage funding of proposals based on achievement of milestones.

Term of Contract:

1 year

Additional Eligibility Criteria:

This award is available to both established and early-career investigators. Established investigators are university faculty at the associate professor level or above, or investigators who hold an equivalent position in a non-university research organization. Early career investigators are defined as a) university faculty at the assistant professor level (or hold an equivalent position in a non-university research organization), b) researchers with an appointment as an instructor or research assistant professor, c) post-doctoral fellows with at least three years of post-doctoral experience or d) clinical fellows. Early career investigators must have a mentor committed to advising the applicant. A clearly articulated mentorship statement from the mentor must be submitted along with the application. See Letter of Intent and Full Proposal Instructions for details.

Cure Epilepsy encourages applications from groups identified as nationally underrepresented in the biomedical, clinical, behavioral, and social sciences. These groups include individuals with disabilities, veterans, persons from underrepresented racial and ethnic groups and gender diverse groups, women in biomedical-related disciplines, or any other characteristic protected by federal, state, or local law are encouraged to apply.

U.S. citizenship is not required. Researchers outside the U.S. are also encouraged to apply.

Members of CURE Epilepsy’s Scientific Advisory Council and their research team members as well as scientific advisors associated with partnering organizations and their research team members are not eligible to apply.

Applications that are strictly focused on basic research including but not limited to gene discovery, understanding cellular pathways and mechanisms, basic electrophysiology etc., without a research tool building component will be given lower priority.

This award is not intended to fund research focusing solely on a comorbid condition associated with a rare epilepsy without also seeking to develop tools to understand the causes and treatments for the accompanying seizures.

Pre-Application Information:

Funding Cycle:
- Open Call for Letters of Intent: Tuesday, May 31, 2022
- Letter of Intent Deadline: Wednesday, June 29, 2022, 9 PM ET
- Full Proposal Invitations: Friday, August 5, 2022
- Full Proposals Due: Tuesday, September 13, 2022, 9 PM ET
- Awardee Notification: December 2022-January 2023
- Anticipated Award Start Date: Spring 2023

All materials must be submitted in English.

For Grant Policies and Forms, see the URL for Full Text link below.

Grant Process:


Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

LOIs must be submitted through proposalCENTRAL (

Questions regarding these guidelines are welcome and should be directed to the Research Team at or 312-255-1801.

Cure Epilepsy
420 N. Wabash Avenue, Suite 650
Chicago, IL 60611
(312) 255-1801

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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