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Grants to USA Nonprofits, For-Profits, Agencies, IHEs, and Tribes for Research Related to AIDS Prevention

HIV Vaccine Research and Design (HIVRAD) Program (P01 Clinical Trial Not Allowed)


GrantWatch ID#

Funding Source
U.S. Department of Health and Human Services (HHS) - National Institutes of Health (NIH)
CFDA Number: 93.855
Funding or PIN Number: PAR-21-024
Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

Geographic Focus
USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);
USA Compact Free Associations:The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)
International, Israel and Canada.

Important Dates
LOI Date: 02/13/23
Deadline: 03/15/23 5:00 PM Save

Grant Description
Grants to USA nonprofit and for-profit organizations, IHEs, government agencies, and tribal organizations for research related to AIDS and HIV. Funding is intended to support projects and studies that are multi-faceted and multi-disciplinary and that address scientific queries relevant to preventive vaccine discovery research.

Applications for five years of support should include plans that have advanced past the exploratory stage and include preliminary data. Applications aimed at developing or optimizing a specific vaccine platform should lay out a research pathway with clear decision points. Extensive evaluation of vaccine concepts in non-human primates may be included.  Small animal models, such as transgenic humanized mice, may be included. 

Applications may address, but need not be limited to:

  • Approaches to elicit durable and broadly neutralizing antibodies against HIV, SIV, and/or SHIV
  • Identifying correlates of vaccine-induced immune protection to HIV/AIDS
  • Structural studies as they relate to designing HIV immunogens
  • Induction and properties of protective non-neutralizing antibodies
  • Improved animal model systems and challenge viruses to address vaccine efficacy
  • Approaches to increasing the immunogenicity of HIV antigens (e.g., adjuvants, nanoparticles)
  • Vaccine design to better address the heterogeneity of HIV
  • Developing or improving viral, bacterial, or other vaccine vectors
  • Determining how immune cells can be mobilized to the portal of infection
  • Investigations into the role of glycan structures on immunogenicity, antigenicity, and infectivity
  • Investigations into innate immunity to alter the outcome of infection.

Research Programs funded under this FOA will be comprised of multiple components.  These are:

  • Administrative Core 
  • Research Projects
  • Scientific Cores
  • External Scientific Advisory Board (SAB)
  • Annual Meetings

For additional information, see the URL for Full Text, below.


  • City or township governments
  • County governments
  • For profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)
  • Small businesses
  • Special district governments
  • State governments

Additional Eligibility Criteria
Eligible Organizations

Higher Education Institutions:
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education

The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Nonprofits Other Than Institutions of Higher Education:
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations:
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)

Local Governments:
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Governments:
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession

- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
- Foreign Institutions

- Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

The following types of studies are non-responsive and will not be reviewed:
- Clinical studies and clinical trials; however, use of existing clinical samples is permitted
- Studies focused solely on therapeutic vaccines

Pre-Application Information
Applications may be submitted from February 15, 2021, through March 15, 2021. Subsequent due dates are March 15, 2022, and March 15, 2023. The program expires on March 16, 2023.

All applications are due by 5:00 PM local time of applicant organization.

Applications may be submitted through ASSIST or through, and may be tracked through eRA Commons.

Applicants must have a DUNS number and be registered with prior to applying. In addition, applicants must register with and with eRA Commons.

Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review. LOIs are due 30 days prior to the application deadline. Submit LOIs to Kumud Singh, Ph.D. (see details below).

Application guide:


Register with

View this opportunity on

For a list of application documents, see the Package tab (press Preview) on the page above.

Additional Funding Information

Estimated Total Program Funding:


Number of Grants
NIH intends to fund an estimate of 1-2 awards

Estimated Size of Grant

Term of Contract
The scope of the proposed project should determine the project period. The maximum project period is 5 years.

The earliest start dates are February 2022, February 2023, and February 2024.

Contact Information
Apply online with ASSIST:

Register with eRA Commons:

Kumud Singh, Ph.D.
Telephone: 301-761-7830

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV

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