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2020 CDKL5 Program of Excellence Pilot Grant Program

Grants to USA, Canada, and International Researchers
to Develop Therapies for Specific Disorders

Agency Type:

Foundation / Corporation

Funding Source:

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University of Pennsylvania School of Medicine - Orphan Disease Center (ODC) and Loulou Foundation

LOI Date:

03/06/20

Deadline Date:

04/03/20 8:00 PM EST

Description:

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Grants to USA, Canada, and International research faculty based at an academic or nonprofit institution for research studies that address a particular treatment-resistant form of epilepsy with concurrent extensive neurodevelopmental delay. Applicants must submit an LOI prior to a full application. Funding is intended to advance the development of therapies for CDKL5 Deficiency Disorder (CDD).

This program is seeking grant applications that progress the discovery or development of treatments and/or a cure for CDKL5 Deficiency. The Foundation recognizes that many gaps exist in the basic understanding of CDKL5 and its role in neurologic development. Therefore, basic science projects that address these gaps are welcome as long as they are tethered to the development of a potential therapy.

While the RFA is broad in scope, priority will be given to grants that cover the following areas:

  1. Novel therapeutic approaches for CDD
  2. Validation of phenotypes in CDKL5 function or disease pathophysiology
  3. Systems biology and computational modeling approaches
  4. Novel application of imaging and functional techniques
  5. Discovery and validation of CDKL5 biomarkers

For more information about the priority areas above, see http://orphandiseasecenter.med.upenn.edu/uploads/attachments/ck6gy8acl4qe5zntudfjq2yrb-2020-cdkl5-rfa-w-patent.pdf#page=1

Allowable direct costs:

  • Salary for PI
  • Salary/stipend and related benefits for graduate student/postdoctoral fellow/technical support
  • Travel (up to $1500)
  • Laboratory supplies and other research expenses

GrantWatch ID#:

GrantWatch ID#: 183153

Number of Grants:

The number of awards may vary.

Estimated Size of Grant:

$150,000 (total cost)

Term of Contract:

Award will be for one year. Proposed funding period: May 1, 2020 – April 30, 20210.

Additional Eligibility Criteria:

All individuals holding a faculty‐level appointment at an academic institution or a senior scientific position at a nonprofit institution or foundation are eligible to respond to this RFA.

Biopharmaceutical companies are not eligible to apply; however, applications from contract research organizations who provide services that are responsive to the RFA will be considered.

Unallowable costs:
- Salary/consultant costs
- Tuition
- Professional membership dues
- Equipment greater than $5,000
- General office supplies, institutional administrative charges (e.g., telephone, other electronic communication, IT network, etc.)
- Pre‐award charges
- Any other expenses not directly related to the project

Pre-Application Information:

All applicants must first submit a Letter of Interest (LOI) to be reviewed for consideration of a full application submission. LOIs must be submitted no later than 5:00 PM (EST) on Friday, March 6, 2020.

Applicants will be notified via email on Monday, March 9, 2020, with a decision regarding their LOI, which, if successful, will invite the applicant to submit a full application.

Full proposals are due Friday, April 3, 2020, no later than 8:00 PM (EST).

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Submit a Letter of Interest:
https://orphandiseasecenter.submittable.com/submit/d1f8dfc4-78de-4155-8a9d-d5048cd647a3/2020-cdkl5-program-of-excellence-pilot-grant-program

For administrative inquiries, please contact:
Samantha Charleston
scharle@upenn.edu
215-573-6822

For scientific inquiries, please email:
Sheridan Carrington, PhD
sjcarr@upenn.edu

University of Pennsylvania
TRL Suite 1200
125 South 31st Street
Philadelphia, PA 19104

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta   British Columbia   Manitoba   New Brunswick   Newfoundland and Labrador   Northwest Territories   Nova Scotia   Nunavut   Ontario   Prince Edward Island   Quebec   Saskatchewan   Yukon

Israel

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